Characterizing the Aggressiveness of Prostate Cancer with Multimodality Imaging
Abstract
The goal of this research project is to demonstrate the ability of multimodality imaging to improve detection of prostate tumors and accurately determine their aggressiveness by comparing non-invasive molecular imaging to pathological examination. Prior to prostatectomy, they will undergo molecular imaging. After prostatectomy, sections of their prostates will be examined under a microscope by a pathologist. This examination is the gold-standard for characterizing tumors and will be used to establish how accurately the pre-surgical multimodality imaging assay was able to find tumors and predict their aggressiveness. We have recruited 14 men into our research study, and they have been imaged with multi-parametric MRI, sodium-MRI and PET using the latest prostate cancer tracer, PSMA-1007, which is now being manufactured at the Nordal Cyclotron and PET Radiochemistry Facility at the Lawson Health Research Institute. Histological examination of the prostate tissue has been completed for these subjects. We constructed an external transmit/receive butterfly RF coil, which eliminates the insertion of an endorectal receive RF coil for sodium-MRI.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2023
- Accession Number
- AD1224412
Entities
People
- Timothy J Scholl
Organizations
- Western University