Accelerating Translation of Estrogen Signaling as a Treatment for Noise-Induced Hidden Hearing Loss in Both Sexes

Abstract

The objective of the proposed project, focused on noise induced hidden hearing loss (NIHHL), is to accelerate translation of biological repair mechanisms following acoustic trauma into therapies that treat auditory system injury and restore auditory function. We plan to test the efficacy of drugs that modulate the estrogen pathway (using estrogen, DPN and Raloxifene) and the mevalonate pathway (using metformin and statins) to prevent/treat NIHHL.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2023
Accession Number
AD1225079

Entities

People

  • Beatrice Milon
  • Benjamin Shuster
  • Carissa Byrd
  • Jessica Mong
  • Reza Amanipour
  • Ronna Hertzano

Organizations

  • University of Maryland, Baltimore

Tags

Readers

  • Auditory Neuroscience/Auditory Physiology.
  • Breast cancer cell signaling and growth regulation.
  • Molecular and Cellular Biology