Hereditary X-Linked Tumor Suppressor Escapes Immune Control in Prostate Cancer
Abstract
In our recent work, we isolated an X-linked signal predisposing men to prostate cancers in 2,700 families ascertained for hereditary ovarian cancers. We sequenced and found a candidate variant on Xq27.2 in MAGEC3 suggesting that HPCX may connect prostate and ovarian cancers. Our preliminary experiments show that, in a tetracycline inducible system, heterologous MAGEC3 may be associated with an anti-proliferative phenotype consistent with a tumor suppressor. We hypothesize that MAGEC3 is a heritable tumor suppressor that is silenced in prostate cancers leading to disease progression. Aim 1 is to confirm the connect between prostate and ovary families by segregation and germline X-chromosome sequencing in family studies and in men with a relevant family history.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 2023
- Accession Number
- AD1225467
Entities
People
- Kent Nastiuk
Organizations
- Health Research, Incorporated