Dissecting Translational Dynamics and Lineage Plasticity in Prostate Cancer
Abstract
Prostate cancer often acquires androgen receptor (AR) independence during treatment via switching to a neuroendocrine phenotype. Whether AR inhibition triggers this lineage plasticity program through translation control remains elusive. Protein synthesis is an important step of gene expression and but how prostate cancer cells regulate mRNA-specific translation is unknown. This study investigates the molecular mechanism underlying phenotype switching in prostate cancer from the translation perspective.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 2024
- Accession Number
- AD1225483
Entities
People
- Yeon S. Kim
Organizations
- Fred Hutchinson Cancer Center