Infrared Spectroscopy of Serum Samples for Disease Diagnostics

Abstract

The fundamental vibrational modes of biological constituents in the tissues and the complex body fluids coincide with optical frequencies in the infrared region. Therefore, spatially resolved molecular compositions and interaction information within the biological materials can be extracted non-destructively using IR radiation without the use of labels or probes. However, the feasibility of this technique to elucidate constituent molecular compositions and interactions within the diagnostic mediums is not well explored. This study demonstrates an application of infrared (IR) spectroscopy of sera for monitoring inflammatory bowel diseases (IBD) and various cancers. Using samples from experimental mice and human patients, the power of IR spectroscopy in structural studies of proteins and other complex band contours are explored to find spectral signatures.

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Document Details

Document Type
Technical Report
Publication Date
May 11, 2021
Accession Number
AD1225956

Entities

People

  • Hemendra M. Ghimire

Organizations

  • Georgia State University

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