Preventing Blood Cancers and Other Malignancies in Military Personnel at Risk Due to Occupational Radiation Exposure
Abstract
We are pursuing a project to examine strategies to promote DNA double strand break repair and thereby prevent and mitigate the toxicity of radiation in the bone marrow and other rapidly proliferative tissues, toward reducing both the acute and delayed effects of radiation, including malignancy. During the third year of research, we pivoted to evaluating a new protective agent. Our in vitro and in vivo studies have established supplementation with oral nicotinamide riboside as a promising means to protect bone marrow from radiation in mice. This approach will be validated during the No Cost Extension.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2023
- Accession Number
- AD1225988
Entities
People
- Stephen J. Kron
Organizations
- University of Chicago