A Blood Test for Diastolic Dysfunction

Abstract

This application sets out to validate a simple, inexpensive blood test to identify DD. Currently, diagnosis depends on costly, time-consuming imaging procedures that are only undertaken after symptoms develop. We have shown in the heart tissues of DD animals (mice and monkeys) and humans that S-Glu-cMyBPC is likely responsible for reduced relaxation in DD and is elevated in the blood. We hypothesize that modified S-Glu-cMyBP-C will be a blood marker for DD. We propose to do a non-interventional human clinical study to validate our animal and preliminary human data.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2024
Accession Number
AD1226023

Entities

People

  • Samuel C. Jr Dudley

Organizations

  • University of Minnesota

Tags

Fields of Study

  • Medicine

Readers

  • Cardiovascular Physiology
  • Computer Science/Computer Engineering/Data Science/Digital Signal Processing.
  • Psychological Intervention/Treatment for Stress, Anxiety, PTSD, and Related Emotional and Cognitive Health Symptoms.