Deciphering Altered Metabolism and Immune Evasion in FAT1-Mutated Head and Neck Cancer

Abstract

To achieve our overall goal of improving precision therapies for HNSCC, we must develop a means to target the sizeable subgroup of these tumors harboring mutation or homozygous deletion of this gene. Unexpectedly, our initial analyses of this new mouse model of HNSCC have revealed a link between FAT1 and metabolic and immunologic alterations, which we this project investigates through 2 specific aims over a 3-year timeline: Aim 1. Define the metabolic processes altered in FAT1-mutated HNSCC tumors Aim 2. Dissect the immunosuppressive mechanisms of FAT1 mutation in the tumor microenvironment.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2023
Accession Number
AD1226357

Entities

People

  • Luc Morris

Organizations

  • Memorial Sloan Kettering Cancer Center

Tags

Fields of Study

  • Biology

Readers

  • Molecular and Cellular Biology
  • Oncology (Cancer Research).
  • Psychological Intervention/Treatment for Stress, Anxiety, PTSD, and Related Emotional and Cognitive Health Symptoms.