EHR-Based Longitudinal Cohort to Explore Pregnancy Outcomes in SLE (ELIPTCL)
Abstract
Systemic Lupus Erythematosus (SLE) is an archetypical autoimmune disease with protean manifestations leading to excessive morbidity and mortality especially as it relates to pregnancy outcomes. Half of all lupus pregnancies result in a loss, preterm birth, and/or preeclampsia, increasing the likelihood of permanent disability to both mother and child. We hypothesize that pregnancies managed according to the ACR Guidelines will have improved maternal, pregnancy, or infant morbidity. ACR-aligned care includes appropriate preconception counseling, pregnancy timed to coincide with quiet disease, pregnancy-compatible medications continued and teratogens stopped preconception, and timely management by rheumatologists and Maternal-Fetal Medicine. The overarching objectives of this proposal are to use Electronic Health Record (EHR)-based tools in the Chicago Area Patient-Centered Outcomes Research Network, CAPriCORN, the Patient-Centered Outcomes Research Network (PCORnet) site in Chicago to describe occurrence and predictors of heterogeneous pregnancy outcomes in maternal SLE across multiple sites, and to assess the impact of ACR guideline-guided care in maternal lupus using real-world data collected at the point of care as the foundation for study evaluation. Women make up a significant proportion of our armed forces and veterans in the US and the active duty female force is racially diverse. Approximately 50% of those women are in their childbearing years and who will need management of reproductive issues.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2023
- Accession Number
- AD1226597
Entities
People
- Rosalind Ramsey-goldman
Organizations
- Northwestern University