Investigation of CytoSorb(trademark) Cytokine and Myoglobin Removal in the Treatment of Trauma and Burn Injury (Cytosorb[trademark])
Abstract
Options for treatment of hyperkalemia in the pre-hospital setting are limited, particularly in the context of natural disaster or combat. Contemporary interventions require extensive resources and technical expertise. Here we utilized a novel and clinically relevant model of ischemia-reperfusion injury inducing acute hyperkalemia to provide evidence for application of extracorporeal hemofiltration technology for serum potassium extraction. We demonstrated that serum potassium can be filtered via hemoperfusion utilizing extracorporeal potassium binding. Hemofiltration to address acute hyperkalemia is feasible with contemporary technology, offering a novel approach to the management of critically ill patients in austere environments. While alternative methods exist to manage hyperkalemia, this technology offers unique advantages to a specific patient base. We believe that continued evolution of extracorporeal hemofiltration alternatives to classic dialysis warrant continued development and evaluation resulting in eventual deployment to serve this unique subset of patients.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 30, 2017
- Accession Number
- AD1226644
Entities
People
- Ian J Stewart
- James D. Ross
- Jason M. Rall
- Kevin K Chung
- Mamie C. Stull
- Michael S. Clemens
Organizations
- 59th Medical Wing