Parameterization of a Systemic Time Dependent Physiological Model for Combined Thermal Burn and Widespread Radiation Injury

Abstract

Multi-test Extended Fourier Amplitude Sensitivity Test (MeFAST), a global sensitivity analysis method, was applied to a time-dependent physiological model for combined injury following thermal burn and widespread radiation exposure. A reduced parameter space was then sampled to obtain a set of reasonable parameter estimates for implementation of the model in relevant software. The methodology presented herein will be used in future work to parameterize other physiologically driven models of combined injury.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 2024
Accession Number
AD1227178

Entities

People

  • Amy Creel
  • Christina Wagner
  • Kyle Gaffney
  • Quintessa Hay
  • Rafael Henriquez-rivera

Organizations

  • Applied Research Associates (United States)

Tags

Readers

  • Computational Modeling and Simulation
  • Neurotrauma and Rehabilitation Medicine.
  • Ocean-Atmosphere Mesoscale Modeling, Data Assimilation, and Flux Boundary Layers

Technology Areas

  • Space