Neuroimaging Endophenotypes and Predictors of Post-Traumatic Brain Injury Dementia in a Nationwide Cohort of Veterans

Abstract

The overall goal is to cost-efficiently harness the newly available wealth of nationwide clinical neuroimaging data and merge with our existing cohort of 1.6 million TBI-exposed and unexposed veterans with up to 12 years of follow-up in order to (1) create a large, nationwide, high-quality cohort of ~200,000 TBI-exposed and un-exposed veterans with MRI imaging data; (2) predict which TBI-exposed veterans will go on to develop dementia; and (3) identify prevalence of specific sub-types of dementia among TBI-exposed versus unexposed veterans. We expect that we will (1) produce the largest military-relevant MRI dataset with expertly curated TBI exposure and dementia outcome and up to 12 years of follow-up (with option of continued follow-up via VHA EMR); (2) develop a method for predicting 5+-year risk of post-TBI dementia using routinely collected clinical MRI. This work may directly inform public health planning within the DoD and VHA and generate testable hypotheses regarding underlying etiology of post-TBI dementia.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2024
Accession Number
AD1227414

Entities

People

  • Duygu Tosun-turgut

Organizations

  • Northern California Institute for Research and Education

Tags

Fields of Study

  • Medicine

Readers

  • Medical Imaging.
  • Mental Health of Military Veterans with Posttraumatic Stress Disorder (PTSD): Risk Factors, Prevalence, Symptoms, and Treatment.
  • Traumatic Brain Injury (TBI) and Cognitive Aging in the Guam and Border Populations Affected by Alzheimer's Disease and Tau-Associated Dementias.