Dissecting the Impact of Mutational Processes on Therapeutic Response in Ovarian Cancer
Abstract
Our hypothesis is that these distinct mutational processes confer differential evolutionary capacity on the malignant cells and impact treatment response. Aim 1 defined the contemporary vs vestigial DNA defects resulting from specific structural mutational processes in HGSOC. Aim 2 defined the functional impact of mutational processes on the transcriptome. Aim 3 tested structural mutational processes as a determinant of response to genotoxic therapy. Our work of detailed genomic and transcriptomic profiling of HGSOC clones provides a high resolution sub-clonal map and points to clone-specific molecular mechanisms that likely underly drug resistance.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2024
- Accession Number
- AD1227421
Entities
People
- Sohrab Shah
Organizations
- Memorial Sloan Kettering Cancer Center