MRI Volumetrics for Risk Stratification of Vision Loss in Optic Pathway Gliomas Secondary to NF1
Abstract
Our overall objective is to develop and validate a novel quantitative MRI analysis software application that will enable: 1) identifying children who are at the greatest risk for vision loss from their NF1-OPG; and 2) making treatment decisions based on accurate evaluation of disease progression and response to therapy. We have completed Tasks 1, 2 and 3 (Aim 1), Task 4-5 (Aim 2) and will present the results of Aim 3 in the summer of 2024despite a majority of the data being analyzed. As previously mentioned, we will be presenting these findings in parallel to the clinical findings of NF1-OPG natural history study results for the very first time. These simultaneous presentation this summer ensures scientific rigor without altering the future study course. Lastly, as the co-PI of theNF1-OPG natural history study (D3 and D4 cohorts), we have the Aim 3 data set in our possession as promised for the NCE. We have not made any significant changes to our study plan.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2023
- Accession Number
- AD1227503
Entities
People
- Robert A. Avery