Rapid Development of Bacterial Toxin neutralizing Small Molecule Chimera

Abstract

During the no-cost extension period, we have conducted fragment-based and DNA-encoded library (DEL) screening efforts to identify authentic ligands for IgG1. Of these two approaches, the DEL approach has proven more successful, leading to the identification of multiple ligands from diverse chemical libraries that are highly enriched in the DEL screen compared to a no-target control experiment.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Apr 02, 2024
Accession Number
AD1227512

Entities

People

  • Craig M. Crews

Organizations

  • Yale University

Tags

Readers

  • Academic Conference Management
  • Molecular Genetics
  • Molecular and Cellular Biochemistry