Trial of the Thrombin-Derived Peptide TP508 for Healing a Combined Radiation Burn Injury
Abstract
This project aligns with the FY21 Military Burn Research Program Idea Development Award focus area of burns in the polytrauma patient with radiation-induced injury. Interventions are needed to optimize healing and return to duty following concomitant injury with burns and radiation. We will test the novel thrombin-derived peptide TP508 in a murine model of combined injury (non-lethal radiation plus contact burn). Prior work demonstrates that TP508 administration improves healing of skin wounds and bone fractures in animals and humans. TP508 has safely administered to ~600 human patients. Although burn wound healing is delayed when coupled with radiation exposure, our preliminary data suggest that normal wound healing can be achieved with TP508 administration. We will now utilize a murine model of sublethal radiation followed by contact burn to test TP508 on healing wounds. This work may provide care solutions by accelerating wound healing, preventing burn wound conversion, and restoring normal healing processes when burns occur with radiation exposure.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2023
- Accession Number
- AD1227931
Entities
People
- Celeste C. Finnety
Organizations
- University of Texas Medical Branch