Dissecting the Role of Cancer Cell Chromatin Remodeling on the Landscape of Tumor Immune Microenvironment
Abstract
We recently demonstrated that the chromatin remodeler Nsd2 is required for PCa metastasis, is associated with tumor progression, and that its silencing markedly reduced the metastatic burden and increased survival. Our preliminary data indicates that Nsd2 antagonizes the SWI/SNF complex deregulating global chromatin accessibility and changes the landscape of the immune infiltrating microenvironment. Further, the remodeling of the immune infiltrate by epigenetic dysregulation is dependent on recurrently altered tumor suppressor genes in mCRPC. This data suggests that epigenetic remodeling altering chromatin accessibility in cancer cells impacts on the tumor immune microenvironment. We hence hypothesize that chromatin accessibility in treatment refractory mCRPC may act as a surrogate marker for epigenetic remodeling that can be correlated to distinct tumor immune infiltration phenotypes with implications for prostate cancer immune checkpoint inhibitors.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2023
- Accession Number
- AD1227971
Entities
People
- Alvaro Aytes