Role of Cholesterol Homeostasis in Lupus Pathogenesis

Abstract

Improper regulation of a specific imit1w1e cell called a B cell has been long linked to the development of SLE. A subtype of B cells, termed Autoimmune/Age-associated B cells (ABC), has recently been shown to play a major role in SLE because of their ability to be major producers of the proteins, also known as autoantibodies, that can cause damage in lupus. Expansion of ABCs in SLE is greater in African-American patients and correlates with disease activity and clinical manifestations. The environmental triggers that promote the accumulation of AB Cs in lupus patients are largely unknown.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2024
Accession Number
AD1228196

Entities

People

  • Alessandra B Pernis

Organizations

  • Hospital for Special Surgery

Tags

Fields of Study

  • Biology
  • Medicine

Readers

  • Immunology and Pathology
  • Naval Engineering and Maritime Security
  • Prostate Cancer Biology.