Leveraging the Framingham Study to Investigate Relationships Between Traumatic Brain Injury, Military Service, Alzheimer's Disease and Related Dementias

Abstract

A large body of evidence suggests that people experiencing a single or repetitive TBI in civilian and military settings may have an increased risk of late-life cognitive decline or neurodegenerative disease, including Alzheimer's disease (AD) and AD-related dementias (ADRD).But the specific clinical features and neuropathological substrates of TBI-associated dementia, as well as the mechanisms underlying this apparent association, are less clear. This project leverages the extensive existing resources of the Framingham Heart Study (FHS), which includes access to a long-committed community-based study sample, as well as health,lifestyle, biomarker, genetic, cognitive, neuroimaging and neuropathological data. We are combining these existing resources with new self-report TBI and military service data. This study will comprehensively characterize the role of TBI and military service on key AD/ADRD outcomes, and identify genetic and non-genetic factors that modify these relationships.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2023
Accession Number
AD1228211

Entities

People

  • Jesse Mez
  • Kristen Dams-o’connor

Organizations

  • Boston Medical Center

Tags

Fields of Study

  • Medicine
  • Psychology

Readers

  • Mental Health of Military Veterans with Posttraumatic Stress Disorder (PTSD): Risk Factors, Prevalence, Symptoms, and Treatment.
  • Traumatic Brain Injury (TBI) and Cognitive Aging in the Guam and Border Populations Affected by Alzheimer's Disease and Tau-Associated Dementias.

Technology Areas

  • Biotechnology