Subchronic Oral Toxicity of 1,1 Diamino 2,2 Dinitroethene (FOX 7) in Rats
Abstract
The acute oral median lethal dose of 1,1-diamino-2,2-dinitroethene (FOX-7) was 875 mg/kg in male rats and 805 mg/kg in female rates. Subacute administration of FOX-7 resulted in 100 mortality at doses>_200 mg/kg-d within 1 week of initiation. Gross pathology indicated mortality was primarily induced by severe gastrointestinal irritation. Male and female rats in the highest dose group (70 mg/kg-d)) of the subchronic study experienced excitability/irritability, seizures, lethargy, rough haircoat, disorientation, squinting, and occasional reductions in body mass. Increased urine volume and nitrite concentration, increased spleen and thyroid mass with associated increased TSH and decreased T4 (female rats only), thrombocytopenia, leukocytosis, and anemia were observed at the highest dose. Decreased epididymal mass and atrophy and degeneration of the testicular spermatogonia were observed in the high-dose male rats. Benchmark dose (BMD) analysis was conducted using dose-dependent reductions in hemoglobin concentration in female rats as the critical effects. The BMD was 12 mg/kg-d and the standard deviation BMDL was 10 mg/kg-d.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 08, 2024
- Accession Number
- AD1228872
Entities
People
- Blas A Guigni
- Lee Crouse
- Matthew A. Bazar
- Meredith E Bohannon
- Taryn K Brown