TOX Report No. S.00899688-23, Feb 2024. Analysis of Kinetics and Potential Biotransformation of PFSAS in Peromyscus with an Updated Dataset
Abstract
This Technical Report describes a toxicokinetic model-based analysis of an updated dataset from samples archived from a study where Peromyscus leucopus were exposed orally to several individual PFAS for 28 days (Toxicological Report No. S.0043781-18). The results of this Technical Report indicate that the observed decreases in PFHxS and 6:2 FTS serum concentrations is likely a result of integrated toxicokinetic processes (i.e., uptake rate, elimination rate, and volume of distribution). This is in contrast to the working hypotheses of Toxicological Report No. S.0043781-18 that either females reached peak serum concentration prior to males (PFHxS) or biotransformation drove serum reductions (6:2 FTS). Based on this toxicokinetic analysis, elimination rate appears to drive the sex-difference observed in maximal serum concentrations in Peromyscus exposed to PFHxS. In Peromyscus exposed to 6:2 FTS there is little indication that loss of 6:2 FTS in serum could be explained by a gain in other PFAS. Excretion, rather than biotransformation, appears to drive the decrease in serum concentrations over the course of exposure.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 23, 2024
- Accession Number
- AD1228881
Entities
People
- Allison M. Narizzano
- Andrew G. East
- Michael J. Quinn