Identifying the Molecular Mechanisms Underlying HIF2-Independent Tumorigenesis in RCC
Abstract
The VHL/HIF-2 axis is considered the fundamental oncogenic pathway in ccRCC. Indeed, VHL is inactivated in over 80 percent of ccRCC. However, the advent of highly specific and effective inhibitors of HIF-2alpha has revealed that HIF-2alpha is dispensable for some ccRCC tumors. Moreover, the rate of response in patients in clinical trials was 15-25 percent. Here, we propose to identify the main oncogenic drivers and molecular pathways that promote tumorigenesis downstream of VHL in a HIF-2-independent manner.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2023
- Accession Number
- AD1228970
Entities
People
- Arijit Mal
Organizations
- University of Texas at Dallas