Identifying Drivers of Therapy Resistance Within the Tumor Microenvironment of Esophageal Adenocarcinoma
Abstract
Gastroesophageal adenocarcinoma is a fast-rising malignancy with a generally poor outcome and a lack of targeted therapy options. Here, we aim to uncover the mechanisms through which the tumor microenvironment (TME) mediates resistance to chemotherapy, with goals of identify novel biomarkers for patient stratification as well as elements within the TME that can be targeted to enhance the efficacy of existing and newly emerging tumor-directed therapies. This will be accomplished via both retrospective and prospective analyses, integrating transcriptomic, genomic, and proteomic analyses with patient-relevant model systems (patient-derived organoids), innovative coculture platforms and high-throughput drug screens.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2023
- Accession Number
- AD1229234
Entities
People
- Lorenzo Ferri
Organizations
- McGill University