Role of Military-Relevant Chlorpyrifos Exposure in Parkinson's Disease-Relevant Dopaminergic Neurotoxicity

Abstract

Given emergent data on chlorpyrifos induced dopaminergic neurotoxicity that may bear relevance to PD, we believe it is critical to understand whether prior military chlorpyrifos exposure may influence PD risk. Thus, we aim to test the following central hypotheses: Military relevant chlorpyrifos exposure causes dopaminergic neurotoxicity and increased risk for Parkinson's disease. We will test our hypothesis through the use of multiple model systems to increase translational value alongside human studies to determine whether likely organophosphate exposure during military service is a risk factor for PD. In testing our hypothesis, we will also explore the basic biology of gene-environment interactions that may potentiate or mitigate the severity and progression of PD-relevant neurotoxicity.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2023
Accession Number
AD1229241

Entities

People

  • Ellen Wells
  • Jason R Cannon

Organizations

  • Purdue University
  • University of Iowa

Tags

Fields of Study

  • Psychology

Readers

  • Neurodegenerative Parkinson's Disease and Rickettsial Disease handbook, including the data level of dopamine, BC, neurons, and PD.
  • Neurotoxicology
  • Theoretical Analysis.