Improving Tendon Repair via Sensory Nerve NGF-TrkA Signaling for Retention on Duty

Abstract

Major tendon injuries represent a significant source of morbidity for military trainees, combat casualties and military veterans. Tendonitis or other tendon injuries represents a significant source of delay in military training. For example, in one long-term observational study following 80,106 active-duty personnel for one year, 450 cases of Achilles tendonitis and 584 cases of patellar tendinopathy were identified91. Furthermore, once injured, a tendon is predisposed to further injury, which sets up the patient for risk of chronic pain, psychosocial distress, and future disability. Better understanding of the pathophysiology of tendon repair will lead to more efficacious treatment strategies. This would represent a high impact on both individual and socioeconomic levels, among military and civilian populations.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2024
Accession Number
AD1229675

Entities

People

  • Aaron W James

Organizations

  • Johns Hopkins University

Tags

Fields of Study

  • Medicine

Readers

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