Uncovering Cellular and Network Mechanisms Underlying Cognitive Deficits in Fragile X Syndrome
Abstract
The overarching goal of this work is to discover ways to counteract deficient neuronal coding of social stimuli, abnormal patterns of hippocampal gamma rhythms, and impaired social behaviors in a rat model of FXS (Fmr1 knockout rats, which we hereafter call FXS rats). During this period, we collected additional place cell recordings from area CA2 in wildtype control animals and FXS rats.We also collected additional olfactory habituation/dishabituation data from FXS rats and wildtype(WT) controls using social and non-social stimuli. We also made progress with our piloting of optogenetic experiments in Aim 2. We also began to test effects of intranasal administration of oxytocin on social exploratory behaviors and CA2 place cell coding. We also began to assess whether oxytocin receptor expression in hippocampal area CA2 differs between FXS rats and WT rats.Our results thus far are significant because they may provide a novel neuronal mechanism that contributes to aberrant social behavior deficits in Fragile X syndrome.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 01, 2023
- Accession Number
- AD1229824
Entities
People
- Colgin Laura
Organizations
- University of Texas at Austin