Peptide-DNA Tiles as Building Blocks for Complex Nanostructures
Abstract
The construction of complex, functional materials that rival the complexity of natural systems is a longstanding goal in nanotechnology. To date, DNA has proved to be one of the most flexible and programmable materials for building complex assemblies. However, DNA nanomaterials are restricted to the physical and chemical properties of the oligonucleotides that comprise them, and are generally limited in their functionality. We propose to develop a novel category of peptide-DNA hybrids in order to merge the chemical and functional diversity of peptides/proteins with the structural complexity of DNA. We will synthesize three new categories of peptide-DNA tiles, based on (1) coiled-coil peptide interactions, (2) collagen triple helices, and (3) trimerizing protein subunits.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 26, 2022
- Accession Number
- AD1230165
Entities
People
- Nicholas Stephanopoulos
Organizations
- Arizona State University