The Prevalence of Alzheimer's Disease Pathology After Traumatic Brain Injury in Veterans and Civilians: A Biomarker Study of Beta-Amyloid and Tau

Abstract

Background: Retrospective studies suggest that traumatic brain injury (TBI) increases the risk of Alzheimers disease (AD)four-fold. This has not been supported by recent PET imaging studies including our previous work. PET scanning to measure the proteins Amyloid and Tau are key predictors of future AD. This study investigates civilians and veterans with single TBI using the latest generation of more sensitive imaging biomarkers.Hypothesis: That individuals with traumatic brain injury (TBI) have a higher prevalence of AD related pathology and neurodegeneration compared to age matched controls.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2023
Accession Number
AD1230179

Entities

People

  • Christopher C Rowe

Organizations

  • University of Melbourne

Tags

Fields of Study

  • Medicine

Readers

  • Oncology and Biomarker-Based Cancer Detection.
  • Traumatic Brain Injury (TBI) and Cognitive Aging in the Guam and Border Populations Affected by Alzheimer's Disease and Tau-Associated Dementias.