In Vitro Stimulation of Lymphocytes from Guinea Pigs Immunized with the Agent of Meningopneumonitis.

Abstract

These studies were undertaken in preparation for an extensive investigation of the association of cell-mediated immunity to chlamydial agents to clinical nongonococcal urethritis. Spleen cells from guinea pigs immunized with the meningopneumonitis strain of Chlamydia psittaci (MN) derived from infected chicken embryos were made to react with MN antigen derived from cell cultures. Lymphocytic blastogenic transformation, production of lymphotoxin, and of migration inhibition factor were demonstrated. The results indicate that these tests can be performed with considerable simplicity with chlamydial antigens. These studies were not applied to nongonococcal urethritis because of the untimely death of Dr. Gordon. (Author)

Document Details

Document Type
Technical Report
Publication Date
Oct 01, 1974
Accession Number
ADA000080

Entities

People

  • Aftab A. Ahmed
  • Emilio Weiss
  • Francis B. Gordon
  • Kenneth W. Sell
  • Richard C. Knudsen

Organizations

  • Naval Medical Research Center

Tags

DTIC Thesaurus Topics

  • Anatomy
  • Biological Sciences
  • Cells
  • Chlamydia
  • Chlamydophila
  • Culture Techniques
  • Hemic And Immune Systems
  • Immunity
  • Inhibition
  • Lymphatic System
  • Lymphocytes
  • Lymphotoxins
  • Migration
  • Production
  • Rodents

Fields of Study

  • Biology
  • Medicine

Readers

  • Immunology
  • Infectious Disease/Epidemiology