The Conversion of Cortisone into Cortisol in the Liver of Guinea Pigs during Allergic Processes of Immediate and Delayed Types,
Abstract
A study was made of the intensity of transformaton of cortisone in to cortisol in anaphylactic alteration of the liver and against the background of experimentally-induced allergic encephalomyelitis (EAE) in guinea pigs under conditions of perfusion of the liver in situ. Introduction of normal horse serum (from 0.02 to 0.2 ml/ml of the perfusate) and egg crystalline albumin (from 10 to 500 gamma/ml) into the perfusate increase the intensity of cortisone transformation into cortisol in the liver of intact guinea pigs; this increase was the greater -- the higher the dose of the antigen. In sensitized guinea pigs administration of the same antigens gave an opposite effect, i.e. a fall of the intensity of cortisol formation from cortisone. Against the background of EAE in animals suffering from marked pareses, the intensity of cortisol formation was greater than in intact animals with any concentration of cortisone in the inflowing perfusate. this evidently serves as one of the causes of an increase of cortisol in guinea pigs with EAE.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 30, 1974
- Accession Number
- ADA000679
Entities
People
- V. I. Pytskii
- Yu. P. Syusyukin
Organizations
- National Air and Space Intelligence Center