Synthesis of New Antimalarial 2-Pyridyl Arylalkanesulfonates.
Abstract
A series of 30 2-pyridyl alpha-toluenesulfonates were prepared for antimalarial testing. These compounds are structural variations of an IMC material, 3,5-dichloro-2-pyridyl alpha-toluenesulfonate (Ay 46069), which had been submitted earlier and found to have activity against P. berghei in mice. Modifications of Ay 46069 made consisted of introducing one or more groups in the alpha-toluenesulfonyl moiety (Br, Cl, F, CF3, CH3) as well as replacement of the Cl in the pyridine ring by Br, CH3O, CH3, and NO2. In some instances a third substituent (Cl, CH3) was placed in the 4- or 6-position of the pyridyl group. In one case, N-sulfonation occurred.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1974
- Accession Number
- ADA000902
Entities
People
- Chi‐Chin Wu
- E. Patrick Lira
- Martin Hamer
- Mary J. Moats
- Othmer F. Batzer