Catalysis by Acetylcholinesterase. Substrate-Mediated Perturbations.
Abstract
The characteristics of the inhibition of acetylcholinesterase by hexamethylenebis(dimethyl(3-phthalimidopropyl)ammonium bromide) (PTP) are both qualitatively and quantitatively different when examined in the presence of the substrates acetylcholine (ACh) and phenyl acetate (PA). Results are interpreted in terms of the Rosenberry and Bernhard (1972) model for acetylcholinesterase catalysis, which involves specific regulatory and inhibitory sites on the enzyme, and offer additional support for this model. Perturbation of the enzyme via such regulatory sites may provide new approaches to prophylaxis and therapy for poisoning by anticholinesterase compounds.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1974
- Accession Number
- ADA001502
Entities
People
- George M. Steinberg
- Joseph W. Amshey Jr.