Experimental Sensitization of Guinea Pigs with Neoarsphenamine,
Abstract
Increased sensitivity of guinea pigs to neoarsphenamine developed 3-4 days after the intradermal administration of 150 micrograms neoarsphenamine and testing with the same compound on the 21st day. The formation of crossed allergic skin reactions with neoarsphenamine (NOVAR) and with related compounds - with salvarsan, osarsol and myarsenol is possible. The intravenous administration of 15 micrograms of neoarspehnamine (NOVAR) before testing selectively delayed the development of contact allergic reactions by more than 144 hours. The intraperitoneal administration of 20 micrograms of neoarsphenamine (NOVAR) in a solution of TWEEN-80 three weeks before sensitization delayed the development of contact allergic skin reactions for a period of up to 140 days from the beginning of sensitization.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 13, 1974
- Accession Number
- ADA001850
Entities
People
- V. A. Ado
Organizations
- National Air and Space Intelligence Center