Phenomenon of Refractivity in an Antiviral Action of Synthetic Polynucleotides
Abstract
Synthetic RNA including complexes of polyinosine and polycytidylic acids (polyI : C), polyguanylic and polycytidylic acids (polyG : C) and others are capable of inducing both in tissue culture and the organisms of laboratory animals two apparently interrelated phenomena that is the development of the antiviral state and induction of interferon formation. An original property of the inductors of interferon formation was discovered and studied to a great extent, to determine development both in vivo and in vitro of the refractivity to repeated stimulation of interferon development. An investigation of the phenomenon resulted in the problem of developing optimum systems for introducing these antiviral preparations as well as a search for methods of overcoming this problem. However, subsequent experiments demonstrated that the antiviral effect develops also at the moment of the condition of refractivity to interferon induction and it is possible that these two phenomena have little in common.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 10, 1974
- Accession Number
- ADA001870
Entities
People
- A. S. Novokhatskii
- F. I. Ershov
Organizations
- United States Army Medical Research Institute of Infectious Diseases