Experimental Sensitization and Nonspecific Desensitization to Bicillin,
Abstract
The author studied desensitizing properties of the combination: aspirin and sodium pangamate to bicillin. Guinea pigs were sensitized with a combination of bicillin with homologic serum of intact animals. Half of the animals daily received the combination of aspirin with sodium pangamate during the process of sensibilization. As an antigen in the booster injection protein complex of penicillin was used. Sensitization was accompanied by an increase in the cardio-vascular system excitability in response to adrenalin introduction. In animals who received aspirin and vitamin B15 only in two cases of 13 a weak anaphylactic reaction developed. In the serum of sensitized guinea pigs antibodies to penicillin were detected by means of the reaction of precipitation in agar. Use of aspirin with vitamin B15 inhibited the formation of antibodies.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 25, 1974
- Accession Number
- ADA004408
Entities
People
- L. P. Shuvalov
Organizations
- National Air and Space Intelligence Center