Temporal Change in Radiosensitivity of Miniature Swine as Evaluated by the Split-Dose Technique

Abstract

Using the split-dose technique, recovery was measured in minature swine exposed to whole-body 60Co gamma radiation delivered at 34-35 rads/minute. The initial conditioning dose (150 rads) was approximately two-thirds of the normal LD50/30 (237 rads). The redetermined or challenge LD50/30 measured 28 days after the conditioning dose was 477 rads, indicating 260 percent recovery from the initial sublethal dose. Histopathological examinations of three animals euthanatized 28 days after 150 rads revealed no histologic evidence that could account for the radioresistant state at that time.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 1974
Accession Number
ADA004597

Entities

People

  • J. E. West
  • J. F. Taylor
  • J. L. Terry
  • M. E. Ekstrom

Organizations

  • Armed Forces Radiobiology Research Institute

Tags

Communities of Interest

  • Advanced Electronics
  • Air Platforms
  • Ground and Sea Platforms
  • Materials and Manufacturing Processes

DTIC Thesaurus Topics

  • Abstracts
  • Anesthesia
  • Blood
  • Bone Marrow
  • Bone Marrow Cells
  • Cells
  • Confidence Limits
  • Data Science
  • Data Storage Systems
  • Depression
  • Experimental Design
  • Gamma Rays
  • Information Science
  • Lethality
  • Mathematical Analysis
  • Radiation
  • Statistical Analysis

Fields of Study

  • Physics

Readers

  • Mathematics or Statistics
  • Nuclear and Radiation Engineering.
  • Toxicology/Environmental Toxicology