Pathophysiological Responses of the Subhuman Primate in Experimental Septic Shock.
Abstract
The serious problem of clinical septic shock has demanded a closer look at the development of a more suitable experimental animal model. The present study was designed to more closely approximate the human clinical entity by studying the cardiovascular-pulmonary-morphologic responses of the baboon to slow infusions of live E. coli organisms. Findings demonstrate notable interactions of cardiovascular-pulmonary dysfunction and renal, cardiac and pulmonary morphological lesions. The baboon shock model appears ideally suited for studies of experimental septic shock and bears suitable resemblance to human clinical entity.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 20, 1975
- Accession Number
- ADA004660
Entities
People
- C. A. Guenter
- E. L. Berrell
- J. J. Coalson
- L. J. Greenfield
- Lerner B. Hinshaw
Organizations
- University of Oklahoma Health Sciences Center