Chemical Factors in Development and Transmission of Human Parasites.
Abstract
The use of residual action repellents and hormones for the protection of houses against infestation by Chagas disease vector Triatoma infestans is described, but results are incomplete as yet. Olivacine, lapachol and 1,3-diphenylpyrazolone inhibit growth of protozoans allied to T. cruzi. Oxamniquine pamoate pellets give three days complete protection against infections by Schistosoma mansoni cercariae, and 87 per cent protection for 10 days. Similar short term protection (3 days) can be obtained with oral lapachol and topical 14,15-epoxygeranylgeraniol. New naturally occurring protective substances are a germacranolide (10-membered unsaturated lactone), lignans, benzofurans and alkaloids (for example, olivacine). Biocidal rubber (M and T, 5% TBTO) gives 7 months control of Biomphalaria tenagophila in still water, in spite of regular artificial repopulation of the site. A soap compounded with sisal juice is toxic to snails at 10mg/liter in 24 h.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 1974
- Accession Number
- ADA005068
Entities
People
- Affonso Do Prado Seabra
- Benjamin Gilbert
- Carl Castleton
Organizations
- Federal University of Rio de Janeiro