Design, Synthesis and Pharmacology of Fluorescent Narcotic Analogs.
Abstract
Fluorescent moieties can be synthesized into narcotic structures with retention of analgesic activity. Substituted acridines are a prolific sources of fluorescent groups which can be synthesized by reasonable methods and introduced into narcotic structures. Favorable spectral properties include the quantum yield of fluorescence, the wavelength of excitation and emission and the extinction coefficient of absorption. Preliminary pharmacological data are reported for a series of fluorescent meperidine analogs.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 15, 1974
- Accession Number
- ADA005081
Entities
People
- Chester M. Himel
- W. Ben Iturrian
Organizations
- University of Georgia