The Effect of Physostigmine on the Memory of a Conditioned Taste Aversion in Rats.
Abstract
A sizable number of experiments have shown that anticholinesterase compounds can produce amnesia for maze learning in rats when the memory for the task is 7 to 14 days old. In this experiment, rats were given physostigmine salicylate (0.5 mg/kg) or saline intraperitoneally and tested for their memory of a conditioned taste aversion acquired 3, 7, 14, or 28 days earlier. No evidence of anticholinesterase-induced amnesia was found using the taste aversion task. The results point out that further work is needed before a general theory of the cholinergic basis of memory can be accepted.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1975
- Accession Number
- ADA005161
Entities
People
- Kenneth Frumkin