Isolation and Characterization of Plasmodial and Babesial Antigens. Revision.
Abstract
In the past year a neutralization test was developed capable of detecting antimerozoite antibody in the serum of rats recovering from malaria. It has been demonstrated that such serum also contains opsonic antibody which markedly stimulates phagocytosis of merozoites by phagocytes from normal rats but does not contain antibody that stimulates phagocytosis of erythrocytes from infected rats. Injection of freeze thawed erythrocytic merozoites protects rats from the effects of challenge with parasitized erythrocytes. It is now possible to determine by immunization and neutralization procedures whether specific antigens associated with erythrocytic merozites significantly contribute to stimulation of immunity in malarious rats.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1975
- Accession Number
- ADA005236
Entities
People
- Julius P. Kreier
Organizations
- Ohio State University