Myocardial Failure with Altered Response to Epinephrine in Endotoxin Shock.
Abstract
The mechanism of myocardial dysfunction in endotoxin shock has been under intense investigation in recent years. The present study assayed various myocardial responses to infused epinephrine after an LD70 endotoxin administration in the isolated instrumented working canine heart preparation exchanging blood with an intact support animal. Epinephrine was periodically administered to hearts at various doses up to 6 hours after endotoxin, during which time cardiac output and afterload were fixed at constant values. Results showed depressions of myocardial responsiveness to epinephrine occurring between 4-6 hours post-endotoxin during the development of heart dysfunction. Depressions in both positive and negative dP/dt and coronary blood flow were observed, while heart rate changes were identical in control (non-shocked) and experimental preparations. Data suggest that the most notable adverse effects of depressed responsiveness may be exerted during myocardial relaxation and diastolic filling, including concomitant restrictions of coronary blood flow.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 18, 1974
- Accession Number
- ADA005520
Entities
People
- Lerner B. Hinshaw
- Linda T. Archer
- M. R. Black
Organizations
- University of Oklahoma Health Sciences Center