The Use of Antileucocytic Serum to Study the Role of Endogenous Pyrogens in the Mechanism of Pyretic Reactions in Immunopathological Processes,
Abstract
Antileucocytic serum (ALS) administered to rabbits produced a marked effect on the content of leucocytes in blood and brought about a rise in body temperature. Addition of ALS to whole rabbit blood leads to the accumulation of endogenous pyrogens in the plasma. Results of this study confirm the possible dependence of pyretic reactions in immunopathological processes on the formation of endogenous pyrogens during the interaction of specific antibodies and leucocytes.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 28, 1975
- Accession Number
- ADA005883
Entities
People
- A. V. Sorokin
- O. A. Elkina
- O. M. Efremov
Organizations
- United States Army Medical Research Institute of Infectious Diseases