Cellular Antigens in the Structure of Venezuelan Equine Encephalomyelitis Virus

Abstract

Venezuelan equine encephalomyelitis virus was found to incorporate into its structures antigens of the cells in which it multiplies. A highly purified virus grown in chick fibroblast cultures was found to have the species- specific antigen, heterogenous Forssman antigen and group A and H antigens. These antigens are localized differently in the virus the species antigen is on the surface, group antigens and heterogenous Forssman antigen are localized deeper and are inaccessible to the effect of specific antibody in native virus. These antigens are detected only after destruction of virions with different detergents. The mechanism of incorporation of these antigens into the virus structure is discussed.

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Document Details

Document Type
Technical Report
Publication Date
Feb 28, 1975
Accession Number
ADA005884

Entities

People

  • F. I. Yershov
  • L. K. Menshikh
  • O. V. Zaitseva
  • P. N. Kosyakov
  • T. A. Posevaya
  • T. M. Sokolova

Organizations

  • United States Army Medical Research Institute of Infectious Diseases

Tags

DTIC Thesaurus Topics

  • Antibodies
  • Antigens
  • Arbovirus Infections
  • Blood
  • Body Fluids
  • Cell Membrane
  • Cells
  • Cellular Structures
  • Centrifuges
  • Detergents
  • Fibroblasts
  • Immune Serums
  • Membranes
  • Security
  • Venezuelan Equine Encephalomyelitis
  • Virology
  • Viruses

Fields of Study

  • Biology

Readers

  • Molecular and Cellular Biochemistry
  • Virology (or Medical Virology).