Isolation of Protective Antigens from Plasmodium Falciparum.
Abstract
The elaboration of an in vitro test for protective malarial antibody has provided a means for assaying extracts from the simian parasite, Plasmodium knowlesi, for protective antigen activity. The purpose of the present work was to set up a similar short-term culture system for the human parasite Plasmodium falciparum which would permit the identification and isolation of protective antigens from this species of malaria. The ultimate objective of the work was to test the effectiveness of these preparations when used as vaccines against erythrocytic infections of P.falciparum in Aotus monkeys. During the initial year attention was directed towards setting up a method of short term in vitro culture of P.falciparum. During the second year the in vitro action of human immune sera on P.falciparum was studied. This in vitro system would provide a suitable means for the identification and isolation of protective antigens from P.falciparum.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1975
- Accession Number
- ADA006224
Entities
People
- G. A. Butcher
- G. H. Mitchell
- S. Cohen