Hemopoietic Stem Cell Migration in Mice of Genotype S1/S1d Following a Single Injection of Bordetella Pertussis Vaccine
Abstract
The ability of a single injection of Bordetella pertussis vaccine to cause an increase in the number of circulating transplantable colony forming units (CFU) in mice of genotype S1/S1d and their normal congeneric littermates was studied. Seventy-six hours after injection of B. pertussis vaccine, the number of circulating CFU per milliliter of blood in normal mice increased from approximately 45 CFU/ml to over 300 CFU/ml, while in S1/S1d mice the number of circulating CFU increased from approximately 22 CFU/ml to only 57 CFU/ml. Thus, the previously reported restriction of splenic CFU growth in S1/S1d mice following multiple injections of endotoxin is discussed in the present work not only in terms of a defect in splenic stromal elements necessary for maximum CFU growth, but also in view of current concepts of CFU migration from marrow to spleen via the circulation.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 01, 1974
- Accession Number
- ADA006791
Entities
People
- K. F. Mccarthy
- T. J. Macvittie
Organizations
- Armed Forces Radiobiology Research Institute