Drug Therapy of Acute Pulmonary Insufficiency
Abstract
The oral or parenteral administration of eriodictyol prevented the appearance of signs of acute pulmonary insufficiency provoked by the following procedures: inhalation of 25% carbon dioxide in oxygen by mice, intraperitoneal injection of paraquat in rats, intravenous injection of endotoxin in rats and intravenous infusion of iodoacetamide in monkeys. Benzoylcarbinolmorpholineacetate hydrochloride (Mobecarbe) is effective in preventing pulmonary lesions induced by inhalation of carbon dioxide in mice. This compound prevented as well as reversed the pulmonary lesions provoked by endotoxin in rats, and by hemorrhagic shock and dextran infusion in monkeys.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 15, 1975
- Accession Number
- ADA007214
Entities
People
- Domingo M. Aviado
Organizations
- University of Pennsylvania