Hemodynamic and Respiratory Responses of Conscious Swine to E. coli Endotoxin.
Abstract
The injection of a sublethal bolus of E. coli endotoxin into conscious swine produced an early increase in pulmonary arterial pressure (PAP) and a decrease in left atrial pressure (LAP). This hemodynamic effect may be secondary to the pulmonary venous constriction seen in other species, or may relate to demonstrated multiple pulmonary microemboli. Hypoxemia developed in only 4 of 17 animals although all endotoxin-treated swine showed interstitial pulmonary edema and elevated wet/dry weight ratios with normal pulmonary surfactant. In addition, endotoxin-treated swine developed signs of disseminated intravascular coagulation with renal cortical infarcts in 44%, and coronary arterial thrombi in 28% including one transmural myocardial infarction. This effect was observed in the absence of prolonged hypotension in swine and should provide a useful model for further study of the relationship of endotoxin to disseminated intravascular coagulation.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 25, 1975
- Accession Number
- ADA008115
Entities
People
- J. J. Coalson
- L. J. Greenfield
- Lerner B. Hinshaw
- P. P. Brown
- R. C. Elkins
Organizations
- University of Oklahoma Health Sciences Center