Hypoglycemia in Lethal Subhuman Primate Septic Shock.
Abstract
Recent research has documented progressively developing hypoglycemia in canine endotoxin shock. The purpose of the present study was to test these findings in a subhuman primate. Experiments were conducted on fasted baboons, anesthetized with sodium pentobarbital and infused with live E. coli organisms. Six of seven baboons died within 26 hours with a mean survival time of 15 hours. Mean systemic pressures declined gradually following onset of organism infusion. An initial variable period of hyperglycemia was observed in six animals followed by 4-15 hours of progressively developing hypoglycemia in all non-surviving animals. Insulin values in arterial blood decreased markedly within four hours after E. coli infusion and remained low (10-20% of control) in all non-surviving animals. Arterial blood lactate and serum potassium progressively rose in animals demonstrating the greatest degree of systemic hypotension, while pH remained relatively constant until preterminal periods.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 12, 1975
- Accession Number
- ADA008116
Entities
People
- B. Benjamin
- F. B. Taylor Jr
- J. J. Coalson
- Lerner B. Hinshaw
- R. C. Elkins
Organizations
- University of Oklahoma Health Sciences Center