Comparative Study of Antimalarial and Other Drugs on G6PD Deficient Red Cells.
Abstract
The correlation between 'in vitro' experiments which utilize the stimulation of the hexose monophosphate shunt (HMS) of normal red cells as a sensitive tool in order to measure the possible hemolytic action of antimalarial drugs, and the 'in vivo' transchromation studies, has been further studied. Chloroquine at the dosage of one gram and WR 142490 AE at the dosage of one gram seem to be devoid of stimulating any hemolytic action on normal glucose 6 phosphate dehydrogenase (G6PD) deficient red cells respectively. On the other hand, sulfalene at the dosage of 1 + 2 g induced both a stimulation of the HMS of normal red cells and destruction of 51 Cr tagged, G6PD deficient cells transfused into normal recipients.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 1974
- Accession Number
- ADA008460
Entities
People
- E. Salvidio
- F. Ajamar
- G. F. Gaetani
- R. Ghio
- R. Ravazzolo
Organizations
- University of Genoa